Drug Information
Drug General Information | |||||
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Drug ID |
D08OQQ
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Former ID |
DIB000512
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Drug Name |
Lavoltidine
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Synonyms |
Loxtidine; AH-234844; GSK-1023911a; GSK-1040323b; Histamine H2 receptor antagonist (GERD), GlaxoSmithKline; Histamine H2 receptor antagonist (gastroesophageal reflux disorder), GlaxoSmithKline
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Drug Type |
Small molecular drug
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Indication | Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] | Discontinued in Phase 2 | [1] | ||
Company |
GlaxoSmithKline plc
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Structure |
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Download2D MOL |
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Formula |
C19H29N5O2
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Canonical SMILES |
c1(cc(ccc1)OCCCNc1nc(nn1C)CO)CN1CCCCC1
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CAS Number |
CAS 76956-02-0
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000092) | ||||
REF 2 | New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16. | ||||
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