Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08OQQ
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| Former ID |
DIB000512
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| Drug Name |
Lavoltidine
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| Synonyms |
Loxtidine; AH-234844; GSK-1023911a; GSK-1040323b; Histamine H2 receptor antagonist (GERD), GlaxoSmithKline; Histamine H2 receptor antagonist (gastroesophageal reflux disorder), GlaxoSmithKline
|
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| Drug Type |
Small molecular drug
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| Indication | Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] | Discontinued in Phase 2 | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H29N5O2
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| Canonical SMILES |
c1(cc(ccc1)OCCCNc1nc(nn1C)CO)CN1CCCCC1
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| CAS Number |
CAS 76956-02-0
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000092) | ||||
| REF 2 | New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16. | ||||
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