Drug Information
Drug General Information | |||||
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Drug ID |
D08OTE
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Former ID |
DIB010413
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Drug Name |
RO-4995819
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Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Discontinued in Phase 2 | [524135] | ||
Company |
F Hoffmann-La Roche Ltd
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Structure |
Download2D MOL |
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Canonical SMILES |
Nc1ccc(cn1)C#Cc2cnn3c(cc(nc23)c4ccc(cc4)C(F)(F)F)C(F)(F<br />)F
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InChI |
1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29)
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InChIKey |
DMJHZVARRXJSEG-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor3 | Target Info | Modulator | [544330] | |
Metabotropic glutamate receptor 2 | Target Info | Modulator | [544330] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Ionotropic glutamate receptor pathway | |||||
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Metabotropic glutamate receptor group II pathway | |||||
References |
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