Drug General Information
Drug ID
D08OTE
Former ID
DIB010413
Drug Name
RO-4995819
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Discontinued in Phase 2 [524135]
Company
F Hoffmann-La Roche Ltd
Structure
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2D MOL

3D MOL

Canonical SMILES
Nc1ccc(cn1)C#Cc2cnn3c(cc(nc23)c4ccc(cc4)C(F)(F)F)C(F)(F<br />)F
InChI
1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29)
InChIKey
DMJHZVARRXJSEG-UHFFFAOYSA-N
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Modulator [544330]
Metabotropic glutamate receptor 2 Target Info Modulator [544330]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 524135ClinicalTrials.gov (NCT01733654) Investigate Efficacy & Safety of RO4995819 vs. Placebo as Adjunct Tx in Patients w/Major Depressive Disorder. U.S. National Institutes of Health.
Ref 544330Novel glutamatergic drugs for the treatment of mood disorders. Neuropsychiatr Dis Treat. 2013; 9: 1101-1112.

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