Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08PBE
|
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| Former ID |
DIB018240
|
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| Drug Name |
[3H]AP4
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C4H10NO5P
|
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| InChI |
InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
|
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| InChIKey |
DDOQBQRIEWHWBT-VKHMYHEASA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3153190, 4252812, 7978716, 10259084, 11113375, 11457587, 11459535, 14818549, 24891296, 26651777, 26758214, 33502534, 49896033, 50104307, 57395670, 78666740, 81093357, 90458771, 103205265, 103920819, 104429542, 117682323, 124635408, 124877291, 124877292, 127719431, 132522189, 134345882, 135158089, 135650507, 135651136, 140341569, 162093643, 163688614, 228129920, 241181546
|
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| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 4 | Target Info | Agonist | [2] | |
| Metabotropic glutamate receptor 8 | Target Info | Agonist | [3] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Taste transductionhsa04080:Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Reactome | G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events | |||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1412). | ||||
| REF 2 | Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. | ||||
| REF 3 | Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. | ||||
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