Drug General Information
Drug ID
D08PMW
Former ID
DIB009901
Drug Name
BMS-223131
Synonyms
4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Phase 2 [527426]
Structure
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2D MOL

3D MOL

Target and Pathway
Target(s) Maxi K potassium channel Target Info Modulator [527426]
KEGG Pathway cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
Salivary secretion
Pancreatic secretion
Reactome cGMP effects
WikiPathways Potassium Channels
Platelet homeostasis
References
Ref 527426Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. Epub 2005 Feb 8.
Ref 527426Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. Epub 2005 Feb 8.

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