Drug General Information
Drug ID	D08QYJ
Former ID	DIB000459
Drug Name	SORETOLIDE
Synonyms	D-2916; Soretolide < Prop INN >; 2,6-Dimethyl-N-(5-methylisozaxol-3-yl)benzamide
Drug Type	Small molecular drug
Indication	Convulsions [ICD9: 780.3; ICD10:R56.0]		Terminated	[545313]
Structure		Download 2D MOL 3D MOL
Formula	C13H14N2O2
Canonical SMILES	Cc1onc(NC(=O)c2c(C)cccc2C)c1
InChI	1S/C13H14N2O2/c1-8-5-4-6-9(2)12(8)13(16)14-11-7-10(3)17-15-11/h4-7H,1-3H3,(H,14,15,16)
InChIKey	GBTKANSDFYFQBK-UHFFFAOYSA-N
CAS Number	CAS 130403-08-6
PubChem Compound ID	198730
Target and Pathway
Target(s)	Glutamate receptor 1	Target Info	Modulator	[532262]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Dopaminergic synapse
	Long-term depression
	Amyotrophic lateral sclerosis (ALS)
	Amphetamine addiction
	Nicotine addiction
PANTHER Pathway	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
Pathway Interaction Database	EPHB forward signaling
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	Trafficking of AMPA receptors
	Trafficking of GluR2-containing AMPA receptors
	Unblocking of NMDA receptor, glutamate binding and activation
	Cargo concentration in the ER
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Amyotrophic lateral sclerosis (ALS)
	BDNF signaling pathway
References
Ref 545313	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002789)
Ref 532262	Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.

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