Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08RVB
|
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| Former ID |
DIB020270
|
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| Drug Name |
LY233053
|
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| Synonyms |
LY-233053; LY 233053
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [467578] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C8H13N5O2
|
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| InChI |
InChI=1S/C8H13N5O2/c14-8(15)6-3-5(1-2-9-6)4-7-10-12-13-11-7/h5-6,9H,1-4H2,(H,14,15)(H,10,11,12,13)/t5-,6+/m0/s1
|
||||
| InChIKey |
FAAVTENFCLADRE-NTSWFWBYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Glutamate [NMDA] receptor subunit epsilon 1 | Target Info | Antagonist | [543837] | |
| Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Antagonist | [543838] | ||
| GluN2D | Target Info | Antagonist | [543840] | ||
| GluN2C | Target Info | Antagonist | [543839] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholism | |||||
| Systemic lupus erythematosushsa04014:Ras signaling pathway | |||||
| Huntington's disease | |||||
| Systemic lupus erythematosus | |||||
| PANTHER Pathway | Huntington disease | ||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Pathway Interaction Database | Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events | ||||
| Reelin signaling pathway | |||||
| References | |||||
| Ref 543837 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). | ||||
| Ref 543838 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). | ||||
| Ref 543839 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). | ||||
| Ref 543840 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). | ||||
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