Drug General Information
Drug ID
D08TKV
Former ID
DIB009216
Drug Name
SKF-97426
Synonyms
SKF-97426A
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [545280]
Company
SmithKline Beecham plc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
C(=O)(C(=C)C)OCCOC(=O)C(=C)C.C(=O)(C(=C)C)OCCCCCCCCCCC[<br />N+](C)(C)C.[Cl-]
CAS Number
CAS 152060-21-4
Target and Pathway
Target(s) Bile acid receptor Target Info Modulator [533930]
KEGG Pathway Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 545280Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002680)
Ref 533930SK&amp;F 97426-A a more potent bile acid sequestrant and hypocholesterolaemic agent than cholestyramine in the hamster. Atherosclerosis. 1993 Jun;101(1):51-60.

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