Drug Information

Drug General Information
Drug ID
D08UOX
Former ID
DNC008401
Drug Name
FALCARINDIOL
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528164]
Structure
Download
2D MOL

3D MOL
Formula
C17H24O2
Canonical SMILES
CCCCCCCC=CC(C#CC#CC(C=C)O)O
InChI
1S/C17H24O2/c1-3-5-6-7-8-9-10-14-17(19)15-12-11-13-16(18)4-2/h4,10,14,16-19H,2-3,5-9H2,1H3/b14-10-/t16?,17-/m0/s1
InChIKey
QWCNQXNAFCBLLV-KJGFWLTQSA-N
PubChem Compound ID
3321
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [529238]
Dopamine D1 receptor Target Info Inhibitor [529238]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [528164]
Kappa-type opioid receptor Target Info Inhibitor [529238]
Delta-type opioid receptor Target Info Inhibitor [529238]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04020:Calcium signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04014:Ras signaling pathway
Calcium signaling pathway
Serotonergic synapsehsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP05912:Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Dopamine Activation of Neurological Reward SystemPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Monoamine GPCRs
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
References
Ref 528164J Nat Prod. 2006 Apr;69(4):536-41.Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Ref 528164J Nat Prod. 2006 Apr;69(4):536-41.Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Ref 529238Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. Epub 2007 Dec 31.Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.

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