Drug Information

Drug General Information
Drug ID
D08WOV
Former ID
DIB018529
Drug Name
2-[125I]melatonin
Synonyms
2-(125I)Iodomelatonin; 2[125I]iodomelatonin; 2-iodo-[125I]-melatonin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538821]
Structure
Download
2D MOL
Formula
C13H15IN2O2
InChI
InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)/i14-2
InChIKey
FJDDSMSDZHURBJ-XSBOKVBDSA-N
PubChem Compound ID
644212
PubChem Substance ID
841873, 43765919, 57408226, 79348310, 109827782, 131271986, 135261189, 135651404
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [534353]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538821(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1344).
Ref 534353Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.