Drug General Information
Drug ID	D08XKO
Former ID	DNC004198
Drug Name	8-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528087]
Structure		Download 2D MOL 3D MOL
Formula	C10H6ClN3O
Canonical SMILES	C1=CC2=NC3=C(C=C2C(=C1)Cl)NC(=O)N3
InChI	1S/C10H6ClN3O/c11-6-2-1-3-7-5(6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
InChIKey	VZXBGYRONYENIL-UHFFFAOYSA-N
PubChem Compound ID	15065155
Target and Pathway
Target(s)	CGMP-inhibited 3',5'-cyclic phosphodiesterase A	Target Info	Inhibitor	[528087]
KEGG Pathway	Purine metabolism
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Morphine addiction
Reactome	cGMP effects
	G alpha (s) signalling events
WikiPathways	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 528087	J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Ref 528087	J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.

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