Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08XNH
|
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| Former ID |
DCL000373
|
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| Drug Name |
GSK221149
|
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| Drug Type |
Small molecular drug
|
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| Indication | Threatened pre-term labour [ICD10:O60.1, P07.3] | Phase 3 | [1] | ||
| Company |
GSK
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C11H13NO8
|
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| Canonical SMILES |
C1=CC(=CC=C1[N+](=O)[O-])OC2C(C(C(C(O2)O)O)O)O
|
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| InChI |
1S/C11H13NO8/c13-7-8(14)10(16)20-11(9(7)15)19-6-3-1-5(2-4-6)12(17)18/h1-4,7-11,13-16H/t7-,8-,9+,10-,11-/m0/s1
|
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| InChIKey |
VZBHOPHDDNTGCY-HHKYUTTNSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Oxytocin receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Oxytocin signaling pathway | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Oxytocin receptor mediated signaling pathway | ||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Myometrial Relaxation and Contraction Pathways | |||||
| Oxytocin signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023904) | ||||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | ||||
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