Drug Information

Drug General Information
Drug ID
D08YVT
Former ID
DNC004557
Drug Name
SCH-211803
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 1 [547376]
Structure
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2D MOL

3D MOL
Formula
C31H36ClN3O3S
Canonical SMILES
CC1=CC=CC(=C1N)C(=O)N2CCC(CC2)N3CCC(CC3)CC4=CC=C(C=C4)S<br />(=O)(=O)C5=CC(=CC=C5)Cl
InChI
1S/C31H36ClN3O3S/c1-22-4-2-7-29(30(22)33)31(36)35-18-14-26(15-19-35)34-16-12-24(13-17-34)20-23-8-10-27(11-9-23)39(37,38)28-6-3-5-25(32)21-28/h2-11,21,24,26H,12-20,33H2,1H3
InChIKey
VMJKUCKTXMESQR-UHFFFAOYSA-N
PubChem Compound ID
9894173
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Inhibitor [526473]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547376Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015639)
Ref 526473J Med Chem. 2002 Dec 5;45(25):5415-8.Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.

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