Drug General Information
Drug ID
D09ADT
Former ID
DNC000130
Drug Name
ABT-418
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 2 [545652]
Structure
Download
2D MOL

3D MOL

Formula
C9H14N2O
Canonical SMILES
CC1=NOC(=C1)C2CCCN2C
InChI
1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
InChIKey
ILLGYRJAYAAAEW-QMMMGPOBSA-N
CAS Number
CAS 147402-53-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-4 chain Target Info Agonist [537889]
Nicotinic acetylcholine receptor Target Info Agonist [534879]
Neuronal acetylcholine receptor protein, beta-2 chain Target Info Agonist [535007], [537889]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
Nicotine Activity on Dopaminergic Neurons
References
Ref 545652Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004036)
Ref 534879Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl). 1999 May;144(2):175-82.
Ref 535007Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44.
Ref 537889(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28.

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