Drug General Information
Drug ID	D09AVG
Former ID	DNC008887
Drug Name	5-amino-3-(N-methylpiperidin-4-yl)-1H-indole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529496]
Structure		Download 2D MOL 3D MOL
Formula	C14H19N3
Canonical SMILES	CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N
InChI	1S/C14H19N3/c1-17-6-4-10(5-7-17)13-9-16-14-3-2-11(15)8-12(13)14/h2-3,8-10,16H,4-7,15H2,1H3
InChIKey	CKBJZDHVHHKARV-UHFFFAOYSA-N
PubChem Compound ID	11831220
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[529496]
	5-hydroxytryptamine 1B receptor	Target Info	Inhibitor	[529496]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signaling
References
Ref 529496	J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.
Ref 529496	J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.

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