Drug General Information
Drug ID	D09BDE
Former ID	DIB008077
Drug Name	PAC-14028
Indication	Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99]		Phase 2	[524628]
Company	Pacific Pharmaceuticals Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Vanilloid receptor 1	Target Info	Antagonist	[531868]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	TRP channels
References
Ref 524628	ClinicalTrials.gov (NCT02052531) Efficacy and Safety Study of PAC-14028 Cream in Dermal Pruritus. U.S. National Institutes of Health.
Ref 531868	Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.