Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09CPC
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| Former ID |
DNC004505
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| Drug Name |
6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one
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| Synonyms |
6-Pyridin-3-yl-3,4-dihydroquinolin-2(1H)-on
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C1CC(=O)NC2=C1C=C(C=C2)C3=CN=CC=C3
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| InChI |
1S/C14H12N2O/c17-14-6-4-11-8-10(3-5-13(11)16-14)12-2-1-7-15-9-12/h1-3,5,7-9H,4,6H2,(H,16,17)
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| InChIKey |
MPGBYGNPFRLHAO-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | CGMP-inhibited 3',5'-cyclic phosphodiesterase A | Target Info | Inhibitor | [1] | |
| Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [2] | ||
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Glucocorticoid biosynthesis | |||||
| Mineralocorticoid biosynthesis | |||||
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Morphine addictionhsa00140:Steroid hormone biosynthesis | |||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Steroidogenesis | ||||
| Reactome | cGMP effects | ||||
| G alpha (s) signalling eventsR-HSA-194002:Glucocorticoid biosynthesis | |||||
| Endogenous sterols | |||||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBaseWP702:Metapathway biotransformation | |||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Corticotropin-releasing hormone | |||||
| References | |||||
| REF 1 | J Med Chem. 1992 Feb 21;35(4):620-8.3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. | ||||
| REF 2 | J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. | ||||
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