Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09DHT
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| Former ID |
DIB020710
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| Drug Name |
phorbol 12-myristate 13-acetate
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| Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C36H56O8
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| InChI |
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
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| InChIKey |
PHEDXBVPIONUQT-RGYGYFBISA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7569, 139224, 492937, 596579, 3154907, 3288052, 7980341, 11120181, 11120669, 11121157, 11121697, 11122177, 11147264, 11342072, 11362255, 11362778, 11365340, 11367902, 11370807, 11370808, 11373503, 11374437, 11376064, 11404383, 11485638, 11487657, 11489727, 11492704, 14789656, 14838769, 17487166, 22391478, 24278653, 24887446, 24898219, 26613354, 26681074, 26681470, 26755285, 34670407, 46487935, 47290908, 47736218, 47885175, 48034851, 50110884, 53790708, 57244624, 57310548, 57652787
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| Target and Pathway | |||||
| Target(s) | KNa1.2 | Target Info | Inhibitor (gating inhibitor) | [2] | |
| Transient receptor potential cation channel subfamily V member 4 | Target Info | Activator | [3] | ||
| KNa1.1 | Target Info | Activator | [2] | ||
| ATP-sensitive K+ channel | Target Info | Inhibitor (gating inhibitor) | [4] | ||
| KEGG Pathway | Inflammatory mediator regulation of TRP channelshsa04713:Circadian entrainment | ||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Estrogen signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Morphine addiction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | TRP channelsR-HSA-1296041:Activation of G protein gated Potassium channels | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | |||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Notch Signaling Pathway | |||||
| Potassium Channels | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2341). | ||||
| REF 2 | Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. | ||||
| REF 3 | Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4. | ||||
| REF 4 | Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. Epub 2004 Jan 19. | ||||
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