Drug General Information
Drug ID
D09DHT
Former ID
DIB020710
Drug Name
phorbol 12-myristate 13-acetate
Synonyms
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539485]
Structure
Download
2D MOL
Formula
C36H56O8
InChI
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) KNa1.2 Target Info Inhibitor (gating inhibitor) [528200]
Transient receptor potential cation channel subfamily V member 4 Target Info Activator [526264]
KNa1.1 Target Info Activator [528200]
ATP-sensitive K+ channel Target Info Inhibitor (gating inhibitor) [526933]
KEGG Pathway Inflammatory mediator regulation of TRP channelshsa04713:Circadian entrainment
Retrograde endocannabinoid signaling
Serotonergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Oxytocin signaling pathway
Morphine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome TRP channelsR-HSA-1296041:Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways Calcium Regulation in the Cardiac Cell
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Notch Signaling Pathway
Potassium Channels
References
Ref 539485(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2341).
Ref 526264Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4.
Ref 526933Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. Epub 2004 Jan 19.
Ref 528200Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68.

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