Drug Information

Drug General Information
Drug ID
D09ESF
Former ID
DNC011367
Drug Name
GNF-PF-78
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531262]
Structure
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2D MOL

3D MOL
Formula
C20H14N2O4
Canonical SMILES
CC1=C(C2=C(O1)C(=O)C3=CC=CC=C3C2=O)C(=O)NCC4=CN=CC=C4
InChI
1S/C20H14N2O4/c1-11-15(20(25)22-10-12-5-4-8-21-9-12)16-17(23)13-6-2-3-7-14(13)18(24)19(16)26-11/h2-9H,10H2,1H3,(H,22,25)
InChIKey
HSYUWLOZMGPYKC-UHFFFAOYSA-N
PubChem Compound ID
2142309
Target and Pathway
Target(s) Nuclear receptor coactivator 3 Target Info Inhibitor [531262]
Sphingosine 1-phosphate receptor 1 Target Info Inhibitor [531262]
KEGG Pathway Thyroid hormone signaling pathwayhsa04068:FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Retinoic acid receptors-mediated signaling
FOXA1 transcription factor networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
MAPK6/MAPK4 signalingR-HSA-418594:G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways DNA Damage Response (only ATM dependent)
EGF/EGFR Signaling Pathway
Nuclear Receptors Meta-Pathway
Pregnane X Receptor pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Integrated Breast Cancer Pathway
Androgen receptor signaling pathwayWP26:Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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