Drug General Information
Drug ID
D09GFL
Former ID
DAP001122
Drug Name
Trihexyphenidyl
Synonyms
Benzhexol; Benzhexolum; Trihexane; Trihexifenidilo; Trihexy; Trihexylphenidyl; Trihexylphenidyle; Trihexylphenizyl; Trihexyphenidyle; Trihexyphenidylum; Triphenidyl; Artane Sequels; PMS Trihexyphenidyl; Parkinane retard; Apo-Trihex; Artane (TN); Sedrena (free base); Trihexifenidilo [INN-Spanish]; Trihexyphenidyl (INN); Trihexyphenidyl [INN:BAN]; Trihexyphenidyle [INN-French]; Trihexyphenidylum [INN-Latin]; Apo-Trihex (TN); Apo-trihex (TN); 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
Drug Type
Small molecular drug
Indication Parkinson's disease; Dystonia [ICD9: 332; ICD10:G20, G24] Approved [536923], [542338], [551871]
Therapeutic Class
Antiparkinson Agents
Company
Lederle Laboratories Div American Cyanamid Co
Structure
Download
2D MOL

3D MOL

Formula
C20H31NO
InChI
InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
InChIKey
HWHLPVGTWGOCJO-UHFFFAOYSA-N
CAS Number
CAS 144-11-6
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N04AA01
SuperDrug CAS ID
cas=000144116
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Antagonist [536802]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
Ref 542338(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7315).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536802The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats. Psychopharmacology (Berl). 2009 Apr;203(2):295-301. Epub 2008 Aug 7.

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