| Drug General Information |
| Drug ID |
D09HXX
|
| Former ID |
DIB021027
|
| Drug Name |
TCN-201
|
| Synonyms |
QCR-22
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C21H17ClFN3O4S
|
| InChI |
InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
|
| InChIKey |
FYIBXBFDXNPBSF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7041295, 9767791, 38901409, 72754086, 75893232, 91979881, 113295701, 164041585, 164137868, 164234011, 164765228, 168274091, 170476518, 170485574, 174006994, 196376834, 223366176, 240299806, 241376840, 242588102, 247315053, 251960702, 252157831, 252450125, 252543621
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Modulator (allosteric modulator) |
[1]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
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Rap1 signaling pathway
|
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
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Circadian entrainment
|
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Long-term potentiation
|
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Glutamatergic synapse
|
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Dopaminergic synapse
|
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
|
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Cocaine addiction
|
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
|
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Systemic lupus erythematosus
|
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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Pathway Interaction Database
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Reelin signaling pathway
|
|
Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
|
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
|
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Alzheimers Disease
|
| References |
| REF 1 | Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci. 2012 May 2;32(18):6197-208. |
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