Drug General Information
Drug ID	D09IHN
Former ID	DNC000674
Drug Name	Gamma-acetylenic GABA
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[537793]
Structure		Download 2D MOL 3D MOL
Formula	C6H9NO2
Canonical SMILES	C#CC(CCC(=O)O)N
InChI	1S/C6H9NO2/c1-2-5(7)3-4-6(8)9/h1,5H,3-4,7H2,(H,8,9)
InChIKey	BJNIHWSOVCDBHS-UHFFFAOYSA-N
CAS Number	CAS 57659-38-8
PubChem Compound ID	3452
PubChem Substance ID	5006225, 8152196, 14991980, 17404701, 24278145, 29222586, 47736697, 47810967, 48259451, 49976796, 50105869, 50105870, 50929439, 53777244, 57321809, 85083259, 85230888, 90341196, 92303419, 99233250, 103137657, 103302389, 104303557, 117548193, 121361022, 124749480, 124879068, 125641817, 127524869, 131342051, 132554872, 134223311, 135073038, 138763257, 162092894, 162875550, 163564092, 226984165
Target and Pathway
Target(s)	4-aminobutyrate aminotransferase, mitochondrial	Target Info	Inhibitor	[537793]
BioCyc Pathway	GABA shunt
	Valine degradation
	Beta-alanine degradation
	4-aminobutyrate degradation
KEGG Pathway	Alanine, aspartate and glutamate metabolism
	Valine, leucine and isoleucine degradation
	beta-Alanine metabolism
	Propanoate metabolism
	Butanoate metabolism
	Metabolic pathways
	GABAergic synapse
PANTHER Pathway	Aminobutyrate degradation
	Pyrimidine Metabolism
	Gamma-aminobutyric acid synthesis
PathWhiz Pathway	Aspartate Metabolism
	Glutamate Metabolism
	Beta-Alanine Metabolism
	Valine, Leucine and Isoleucine Degradation
	Propanoate Metabolism
WikiPathways	GABA synthesis, release, reuptake and degradation
	Alanine and aspartate metabolism
References
Ref 537793	Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. Neurology. 1981 Feb;31(2):207-11.
Ref 537793	Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. Neurology. 1981 Feb;31(2):207-11.

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