Drug Information

Drug General Information
Drug ID
D09JVV
Former ID
DIB000333
Drug Name
Physostigmine
Synonyms
Xalieve; Acetylcholinesterase inhibitor (dry mouth), Calabar; Physostigmine (local acting gel, xerostomia); Physostigmine (buccal, xerostomia), Calabar; Physostigmine (local acting gel, xerostomia), Calabar
Drug Type
Small molecular drug
Indication Xerostomia [ICD9: 527.7; ICD10:K11.7, R68.2] Discontinued in Phase 2 [541716], [548786]
Company
Calabar AB
Structure
Download
2D MOL

3D MOL
Formula
C15H21N3O2
InChI
InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
InChIKey
PIJVFDBKTWXHHD-HIFRSBDPSA-N
PubChem Compound ID
5983
PubChem Substance ID
8765, 89892, 7847264, 7979185, 8138132, 8153719, 11341652, 11361835, 11363810, 11364692, 11366372, 11367254, 11368934, 11369816, 11371789, 11371941, 11374571, 11375199, 11375666, 11377096, 11377979, 11466594, 11467714, 11484075, 11484510, 11485021, 11486307, 11487237, 11488146, 11488573, 11489099, 11490361, 11490716, 11492811, 11493445, 11493727, 11494730, 11495603, 11537599, 14848555, 15222048, 17405046, 24277867, 24869283, 25626763, 26612055, 26679946, 26753571, 26753572, 29224999
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [533483]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 541716(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6598).
Ref 548786Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028816)
Ref 533483The effects of physostigmine on acetylcholinesterase activity of CSF plasma and brain. A comparison of intravenous and intraventricular administration in beagle dogs. Neuropharmacology. 1986 Oct;25(10):1167-77.

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