Drug Information

Drug General Information
Drug ID
D09KSE
Former ID
DNC000968
Drug Name
Mu O-conotoxin
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [535930]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C22H18N6
Canonical SMILES
CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N
InChI
1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChIKey
YIBOMRUWOWDFLG-ONEGZZNKSA-N
CAS Number
CAS 500287-72-9
PubChem Compound ID
6451164
PubChem Substance ID
3718286, 11972346, 14926256, 43042131, 47211694, 47211697, 47211721, 51661424, 57370287, 68530819, 92765310, 92765312, 99445063, 103439143, 104226189, 114526520, 118855328, 124490460, 126650351, 126671558, 131316308, 131465251, 134340246, 134340430, 135246698, 136946573, 137035212, 137185600, 139360872, 144115326, 152041099, 152258256, 160645811, 160647092, 160778753, 160778853, 160778857, 160778861, 160778873, 160778877, 160778884, 160969625, 162011442, 162197408, 162211538, 163884612, 164764879, 164834289, 172121854, 175268205
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Inhibitor [535930]
Reactome Interaction between L1 and Ankyrins
References
Ref 535930Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem. 2004 Jun 11;279(24):25774-82. Epub 2004 Mar 24.
Ref 535930Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem. 2004 Jun 11;279(24):25774-82. Epub 2004 Mar 24.

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