Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09LXQ
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| Former ID |
DIB018107
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| Drug Name |
(S)-5-fluorowillardiine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [540665] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C7H8FN3O4
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| InChI |
InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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| InChIKey |
DBWPFHJYSTVBCZ-BYPYZUCNSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
826825, 7887667, 7979248, 8026775, 10241608, 11113439, 29306101, 46392541, 46506706, 47434926, 47880175, 56311653, 57341831, 76410661, 91746236, 103349388, 103956312, 104363948, 121360551, 127712132, 135083876, 135610254, 137005645, 137275664, 137323788, 140862486, 141003648, 160966124, 163058439, 178100893, 184527083, 184587784, 196680065, 198184233, 198184237, 198184239, 198184241, 230875271, 238317452, 241034602, 241181609, 241376239, 252474685
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| Target and Pathway | |||||
| Target(s) | Glutamate receptor 4 | Target Info | Agonist | [543830] | |
| Glutamate receptor 1 | Target Info | Agonist | [543827] | ||
| Glutamate receptor 3 | Target Info | Agonist | [543829] | ||
| Glutamate receptor 2 | Target Info | Agonist | [543828] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Amphetamine addiction | |||||
| Nicotine addictionhsa04024:cAMP signaling pathway | |||||
| Long-term potentiation | |||||
| Long-term depression | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Nicotine addiction | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | EPHB forward signalingncadherinpathway:N-cadherin signaling events | ||||
| Reactome | Trafficking of AMPA receptors | ||||
| Trafficking of GluR2-containing AMPA receptors | |||||
| Unblocking of NMDA receptor, glutamate binding and activationR-HSA-204005:COPII (Coat Protein 2) Mediated Vesicle Transport | |||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| Cargo concentration in the ER | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction | |||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| BDNF signaling pathway | |||||
| References | |||||
| Ref 543827 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). | ||||
| Ref 543828 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). | ||||
| Ref 543829 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). | ||||
| Ref 543830 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). | ||||
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