Drug General Information
Drug ID	D09LZA
Former ID	DNCL003440
Drug Name	CS-4771
Indication	Sepsis [ICD9: 995.91; ICD10:A40, A41]		Discontinued in Phase 1	[549092]
Company	Daiichi Sankyo
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Toll-like receptor 4	Target Info	Modulator	[551205]
KEGG Pathway	NF-kappa B signaling pathway
	HIF-1 signaling pathway
	Phagosome
	PI3K-Akt signaling pathway
	Toll-like receptor signaling pathway
	Pathogenic Escherichia coli infection
	Salmonella infection
	Pertussis
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Malaria
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Hepatitis B
	Measles
	Influenza A
	Proteoglycans in cancer
	Inflammatory bowel disease (IBD)
	Rheumatoid arthritis
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
	IL4 Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Pathway Interaction Database	Endogenous TLR signaling
Reactome	Ligand-dependent caspase activation
	Toll Like Receptor 4 (TLR4) Cascade
	MyD88:Mal cascade initiated on plasma membrane
	MyD88-independent TLR3/TLR4 cascade
	TRIF-mediated programmed cell death
	MyD88 deficiency (TLR2/4)
	IRAK4 deficiency (TLR2/4)
	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
	IKK complex recruitment mediated by RIP1
	TRAF6 mediated induction of TAK1 complex
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88:Mal cascade initiated on plasma membrane
	MyD88-independent cascade
	Primary Focal Segmental Glomerulosclerosis FSGS
	Spinal Cord Injury
	Corticotropin-releasing hormone
	Pathogenic Escherichia coli infection
	Regulation of toll-like receptor signaling pathway
References
Ref 549092	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032166)
Ref 551205	Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013

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