Drug General Information
Drug ID	D09MJO
Former ID	DIB001080
Drug Name	HL-004
Synonyms	TS-962
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Preclinical	[549199]
Company	Taisho Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(C(C)C)cccc1C(C)C)NC(=O)CSCCCCCCCCCCCCCC
CAS Number	CAS 144288-97-1
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534440]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 549199	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033616)
Ref 534440	ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004. Atherosclerosis. 1997 Aug;133(1):97-104.

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