Drug Information

Drug General Information
Drug ID
D09OCK
Former ID
DNC009615
Drug Name
UK-371800
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Phase 1 [529766]
Structure
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2D MOL

3D MOL
Formula
C23H33N7O5S
Canonical SMILES
CCC1=C2C(=NN1C)C(=O)N=C(N2)C3=CC(=CN=C3OC(C)COC)S(=O)(=<br />O)N4CCN(CC4)CC
InChI
1S/C23H33N7O5S/c1-6-18-19-20(27-28(18)4)22(31)26-21(25-19)17-12-16(13-24-23(17)35-15(3)14-34-5)36(32,33)30-10-8-29(7-2)9-11-30/h12-13,15H,6-11,14H2,1-5H3,(H,25,26,31)/t15-/m1/s1
InChIKey
WKISNFXGTYNPOO-OAHLLOKOSA-N
PubChem Compound ID
9849520
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [529766]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 529766Bioorg Med Chem Lett. 2008 Dec 1;18(23):6033-6. Epub 2008 Oct 11.Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.
Ref 529766Bioorg Med Chem Lett. 2008 Dec 1;18(23):6033-6. Epub 2008 Oct 11.Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.

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