Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09OHS
|
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| Former ID |
DIB018613
|
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| Drug Name |
4alpha-PDD
|
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| Synonyms |
4alpha-phorbol 12,13-didecanoate; 4alpha-phorbol-didecanoate
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C40H64O8
|
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| InChI |
InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
|
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| InChIKey |
DGOSGFYDFDYMCW-OEFRVDPMSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Transient receptor potential cation channel subfamily V member 4 | Target Info | Activator | [2] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | ||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2500). | ||||
| REF 2 | Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4. | ||||
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