Drug Information

Drug General Information
Drug ID
D09RXU
Former ID
DNC010073
Drug Name
2-Benzyl-4-piperazin-1-yl-1H-benzimidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530637]
Structure
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2D MOL

3D MOL
Formula
C18H20N4
Canonical SMILES
C1CN(CCN1)C2=CC=CC3=C2N=C(N3)CC4=CC=CC=C4
InChI
1S/C18H20N4/c1-2-5-14(6-3-1)13-17-20-15-7-4-8-16(18(15)21-17)22-11-9-19-10-12-22/h1-8,19H,9-13H2,(H,20,21)
InChIKey
YTVICZASURPPDE-UHFFFAOYSA-N
PubChem Compound ID
45488131
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [530637]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530637J Med Chem. 2010 Feb 11;53(3):1357-69.Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.
Ref 530637J Med Chem. 2010 Feb 11;53(3):1357-69.Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

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