Drug Information

Drug General Information
Drug ID
D09SXN
Former ID
DIB020307
Drug Name
MAP4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538891]
Structure
Download
2D MOL
Formula
C5H12NO5P
InChI
InChI=1S/C5H12NO5P/c1-5(6,4(7)8)2-3-12(9,10)11/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11)/t5-/m0/s1
InChIKey
HONKEGXLWUDTCF-YFKPBYRVSA-N
PubChem Compound ID
1795545
PubChem Substance ID
7979860, 10666931, 11113658, 15340417, 26751849, 34978081, 57409211, 74694867, 91746355, 110663829, 126645245, 128090508, 132555160, 135650565, 137094766, 140384409, 226540682, 241181840, 242290305
Target and Pathway
Target(s) Metabotropic glutamate receptor 8 Target Info Antagonist [525723]
Metabotropic glutamate receptor 7 Target Info Antagonist [525945]
mGlu6 receptor Target Info Antagonist [526630]
Metabotropic glutamate receptor 4 Target Info Antagonist [525456]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
References
Ref 538891(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1414).
Ref 525456Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
Ref 525723Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90.
Ref 525945Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
Ref 526630The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317.

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