Drug Information

Drug General Information
Drug ID
D09VAB
Former ID
DIB014596
Drug Name
BPR1K-0224
Synonyms
Aurora kinase inhibitors (cancer); BPR1K-0025; BPR1K-0224; BPR1K-0432; BPR1K-0648; BPR1K-0724; Aurora kinase inhibitors (cancer), National Health Research Institutes
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543524]
Company
National Health Research Institutes
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(ccccc1)[C@@H](CO)Nc1ncnc2c1c(c(o2)c1ccccc1)c1cccc(c1<br />)NC(=O)C=C
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [543524]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

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