Drug General Information
Drug ID
D09VWI
Former ID
DIB011115
Drug Name
BRX-005
Synonyms
Arimoclomol maleate; BRX-005; BRX-220; Bimoclomol derivatives, Biorex
Indication Amyotrophic lateral sclerosis [ICD9: 335.2; ICD10:G12.2] Discontinued in Phase 2 [534488]
Company
Biorex Research and Development Co
Structure
Download
2D MOL

3D MOL

Canonical SMILES
[n+]1(cc(/C(=N/OC[C@@H](CN2CCCCC2)O)/Cl)ccc1)[O-].C(=O)<br />(/C=C\C(=O)O)O
CAS Number
CAS 289893-26-1
Target and Pathway
Target(s) Heat shock protein 70 Target Info Modulator [525882]
References
Ref 534488Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med. 1997 Oct;3(10):1150-4.
Ref 525882Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9.

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