Drug Information
Drug General Information | |||||
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Drug ID |
D09VXM
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Former ID |
DNAP001270
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Drug Name |
Crofelemer
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Synonyms |
Fulyzaq (TN)
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Drug Type |
Small molecular drug
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Company |
Salix
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Structure |
Download2D MOL |
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Formula |
C18H16N2O3
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Canonical SMILES |
COC1=CC=CC=C1CNC(=O)C2=NOC(=C2)C3=CC=CC=C3
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InChI |
1S/C18H16N2O3/c1-22-16-10-6-5-9-14(16)12-19-18(21)15-11-17(23-20-15)13-7-3-2-4-8-13/h2-11H,12H2,1H3,(H,19,21)
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InChIKey |
JDNAIBCYTQGWFC-UHFFFAOYSA-N
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CAS Number |
CAS 148465-45-6
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | calcium activated channel anoctamin 1 | Target Info | Modulator | [530433], [532210] | |
cystic fibrosis transmembrane conductance regulator | Target Info | Modulator | [530433], [532210] | ||
WikiPathways | ABC-family proteins mediated transport | ||||
References | |||||
Ref 530433 | Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan;77(1):69-78. | ||||
Ref 532210 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
Ref 542477 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7453). |
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