Drug General Information
Drug ID
D09VXM
Former ID
DNAP001270
Drug Name
Crofelemer
Synonyms
Fulyzaq (TN)
Drug Type
Small molecular drug
Indication HIV-associated diarrhoea [ICD10:A09] Approved [530433], [532210], [542477]
Company
Salix
Structure
Download
2D MOL

3D MOL

Formula
C18H16N2O3
Canonical SMILES
COC1=CC=CC=C1CNC(=O)C2=NOC(=C2)C3=CC=CC=C3
InChI
1S/C18H16N2O3/c1-22-16-10-6-5-9-14(16)12-19-18(21)15-11-17(23-20-15)13-7-3-2-4-8-13/h2-11H,12H2,1H3,(H,19,21)
InChIKey
JDNAIBCYTQGWFC-UHFFFAOYSA-N
CAS Number
CAS 148465-45-6
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) calcium activated channel anoctamin 1 Target Info Modulator [530433], [532210]
cystic fibrosis transmembrane conductance regulator Target Info Modulator [530433], [532210]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome Stimuli-sensing channelsR-HSA-382556:ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 530433Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan;77(1):69-78.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 542477(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7453).
Ref 530433Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan;77(1):69-78.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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