Drug Information
Drug General Information | |||||
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Drug ID |
D09YEQ
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Former ID |
DIB020835
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Drug Name |
Ro4491533
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Synonyms |
Ro 4491533; Ro-4491533
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [541396] | ||
Structure |
Download2D MOL |
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Formula |
C24H20F3N3O
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InChI |
InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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InChIKey |
LYTVXCQQTLUEQR-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor3 | Target Info | Modulator (allosteric modulator) | [531231] | |
Metabotropic glutamate receptor 2 | Target Info | Modulator (allosteric modulator) | [531703] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Ionotropic glutamate receptor pathway | |||||
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Metabotropic glutamate receptor group II pathway | |||||
References | |||||
Ref 531231 | Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6969-74. | ||||
Ref 531703 | Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011 Dec;25(4):152-66. |
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