Drug General Information |
Drug ID |
D09YHQ
|
Former ID |
DNC008056
|
Drug Name |
9-chlorobenzo[h]isoquinolin-1(2H)-one
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C13H8ClNO
|
Canonical SMILES |
C1=CC2=C(C3=C1C=CC(=C3)Cl)C(=O)NC=C2
|
InChI |
1S/C13H8ClNO/c14-10-4-3-8-1-2-9-5-6-15-13(16)12(9)11(8)7-10/h1-7H,(H,15,16)
|
InChIKey |
XSQDWQSZUGGKPF-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Serine/threonine-protein kinase Chk1 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Cell cycle
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p53 signaling pathway
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HTLV-I infection
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Viral carcinogenesis
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Pathway Interaction Database
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Fanconi anemia pathway
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p73 transcription factor network
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ATR signaling pathway
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Circadian rhythm pathway
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p53 pathway
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Reactome
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Activation of ATR in response to replication stress
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Processing of DNA double-strand break ends
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Presynaptic phase of homologous DNA pairing and strand exchange
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G2/M DNA damage checkpoint
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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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WikiPathways
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DNA Damage Response
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Signaling by SCF-KIT
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Integrated Pancreatic Cancer Pathway
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Prostate Cancer
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Cell Cycle
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage Response
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References |
REF 1 | Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. Epub 2007 Sep 7.Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. |