| Drug General Information |
| Drug ID |
D09YTH
|
| Former ID |
DIB012977
|
| Drug Name |
CPU-228
|
| Synonyms |
Dofetilide analog (cardiac failure), China Pharmaceutical University
|
| Drug Type |
Small molecular drug
|
| Indication |
Cardiac failure [ICD10:I50]
|
Investigative |
[1]
|
|---|
| Company |
China Pharmaceutical University
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H26N2O4S
|
| Canonical SMILES |
c12c(cccc1cccc2)OCCN(CCc1ccc(cc1)NS(=O)(=O)C)C(=O)C
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Voltage-dependent L-type calcium channel subunit alpha-1C |
Target Info |
Modulator |
[2]
|
|---|
| Voltage-dependent P/Q-type calcium channel alpha-1A subunit |
Target Info |
Modulator |
[3]
|
| Voltage-dependent L-type calcium channel alpha-1D subunit |
Target Info |
Modulator |
[4]
|
| Voltage-dependent R-type calcium channel alpha-1E subunit |
Target Info |
Modulator |
[1]
|
| Voltage-dependent N-type calcium channel |
Target Info |
Modulator |
[5]
|
|
KEGG Pathway
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MAPK signaling pathway
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Cardiac muscle contraction
|
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Insulin secretion
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GnRH signaling pathway
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Oxytocin signaling pathway
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Type II diabetes mellitus
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Alzheimer's disease
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Amphetamine addiction
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Hypertrophic cardiomyopathy (HCM)
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Arrhythmogenic right ventricular cardiomyopathy (ARVC)
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Dilated cardiomyopathyhsa04010:MAPK signaling pathway
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Synaptic vesicle cycle
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Long-term depression
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Taste transduction
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Morphine addiction
|
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Nicotine addictionhsa04010:MAPK signaling pathway
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Carbohydrate digestion and absorption
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Type II diabetes mellitushsa04010:MAPK signaling pathway
|
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Nicotine addiction
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NetPath Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Nicotinic acetylcholine receptor signaling pathway
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5HT2 type receptor mediated signaling pathway
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Beta1 adrenergic receptor signaling pathway
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Beta2 adrenergic receptor signaling pathway
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Oxytocin receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group II pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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Endogenous cannabinoid signaling
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GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
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Oxytocin receptor mediated signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Thyrotropin-releasing hormone receptor signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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GABA-B receptor II signaling
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PathWhiz Pathway
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Muscle/Heart ContractionPW000619:Pancreas Function
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Reactome
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Adrenaline,noradrenaline inhibits insulin secretion
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NCAM1 interactions
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Regulation of insulin secretionR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
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Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
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WikiPathways
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Calcium Regulation in the Cardiac Cell
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Arrhythmogenic Right Ventricular Cardiomyopathy
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Alzheimers Disease
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NCAM signaling for neurite out-growth
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Integration of energy metabolism
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Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
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Synaptic Vesicle Pathway
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Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
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Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534). |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529). |
|---|
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 532). |
|---|
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530). |
|---|
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533). |
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