Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09YTY
|
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| Former ID |
DIB000394
|
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| Drug Name |
Osutidine
|
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| Synonyms |
T-593
|
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| Drug Type |
Small molecular drug
|
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| Indication | Duodenal ulcers [ICD10:K25-K27] | Discontinued in Phase 3 | [1] | ||
| Company |
Toyama Chemical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H28N4O5S2
|
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| Canonical SMILES |
S(=O)(=O)(/N=C(\NCC(c1ccc(cc1)O)O)/NCCSCc1oc(cc1)CNC)C
|
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| CAS Number |
CAS 140695-21-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002012) | ||||
| REF 2 | Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50. | ||||
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