Drug General Information
Drug ID	D09YTY
Former ID	DIB000394
Drug Name	Osutidine
Synonyms	T-593
Drug Type	Small molecular drug
Indication	Duodenal ulcers [ICD10:K25-K27]		Discontinued in Phase 3	[545064]
Company	Toyama Chemical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C19H28N4O5S2
Canonical SMILES	S(=O)(=O)(/N=C(\NCC(c1ccc(cc1)O)O)/NCCSCc1oc(cc1)CNC)C
CAS Number	CAS 140695-21-2
PubChem Compound ID	132303
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Antagonist	[525983]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545064	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002012)
Ref 525983	Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50.

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