Drug Information
Drug General Information | |||||
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Drug ID |
D0A2IH
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Former ID |
DIB013879
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Drug Name |
KU-1257
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Drug Type |
Small molecular drug
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Indication | Duodenal ulcers [ICD10:K25-K27] | Discontinued in Phase 3 | [1] | ||
Company |
Kyorin Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C18H29N3O2
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Canonical SMILES |
C(=O)(NCCCOc1cc(CN2CCCCC2)ccc1)NCC
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CAS Number |
CAS 120958-90-9
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001852) | ||||
REF 2 | Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33. | ||||
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