Drug Information

Drug General Information
Drug ID
D0A2OW
Former ID
DNC001068
Drug Name
Otenzepad
Drug Type
Small molecular drug
Indication Heart failure [ICD9: 428; ICD10:I50] Discontinued in Phase 2 [540091], [544816]
Structure
Download
2D MOL

3D MOL
Formula
C24H31N5O2
InChI
InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChIKey
UBRKDAVQCKZSPO-UHFFFAOYSA-N
CAS Number
CAS 100158-38-1
PubChem Compound ID
107867
PubChem Substance ID
239489, 510727, 5530915, 10234472, 11426578, 12013665, 14929469, 26719787, 26752073, 44436806, 46386986, 47423785, 47499112, 47572939, 48242935, 49681762, 50034619, 50917362, 57338297, 85229917, 85788636, 91746553, 92098548, 92308468, 103181030, 103929232, 104379928, 124659038, 124886981, 129345351, 134340056, 134340317, 135066279, 135132787, 135649900, 135698213, 139732225, 144204493, 162022222, 162022958, 163122876, 170466332, 170485721, 172080425, 172657833, 179149480, 179295983, 184536610, 184547112, 204380666
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Antagonist [535357]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540091(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 309).
Ref 544816Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001216)
Ref 535357Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S43-9.

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