Drug Information

Drug General Information
Drug ID
D0A8EK
Former ID
DIB018866
Drug Name
APNEA
Synonyms
N6-2-(4-aminophenyl)ethyladenosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467508]
Structure
Download
2D MOL
Formula
C18H22N6O4
InChI
InChI=1S/C18H22N6O4/c19-11-3-1-10(2-4-11)5-6-20-16-13-17(22-8-21-16)24(9-23-13)18-15(27)14(26)12(7-25)28-18/h1-4,8-9,12,14-15,18,25-27H,5-7,19H2,(H,20,21,22)
InChIKey
XTPOZVLRZZIEBW-UHFFFAOYSA-N
PubChem Compound ID
4397
PubChem Substance ID
7377600, 17404681, 26753523, 29223494, 47440468, 50105846, 50105847, 53777224, 56204339, 76338930, 85209413, 85230887, 90340603, 92303584, 103837799, 103945282, 104306286, 117523293, 121360942, 124749463, 124879066, 124879067, 135649949, 135651138, 163564072, 179293815, 242084478
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Agonist [534821]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467508(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 417).
Ref 534821Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.