Drug Information

Drug General Information
Drug ID
D0A9ED
Former ID
DNC000387
Drug Name
Carazolol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541032]
Structure
Download
2D MOL

3D MOL
Formula
C18H22N2O2
InChI
InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
InChIKey
BQXQGZPYHWWCEB-UHFFFAOYSA-N
CAS Number
CAS 51997-43-4
PubChem Compound ID
71739
PubChem Substance ID
6685022, 7978853, 8194800, 15468496, 43128022, 50022846, 51091918, 57318337, 79557571, 85208998, 91611495, 103089481, 103153519, 103331481, 103937132, 104351190, 117613301, 126671688, 127555400, 134339829, 135029386, 135650054, 136161295, 137024393, 137251459, 162185417, 162251286, 162863557, 164786782, 172089152, 179150703, 184545382, 206246514, 223674687, 223704591, 226457254, 226457255, 250061443, 251890234, 252359210, 252390123
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Agonist [538095]
Beta-3 adrenergic receptor Target Info Agonist [538095]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 541032(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 569).
Ref 538095Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.

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