Drug Information

Drug General Information
Drug ID
D0AP6N
Former ID
DNC005853
Drug Name
1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527668]
Structure
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2D MOL

3D MOL
Formula
C16H24N2O
Canonical SMILES
CCCCN1C=C(C2=C1C=CC=C2O)CCN(C)C
InChI
1S/C16H24N2O/c1-4-5-10-18-12-13(9-11-17(2)3)16-14(18)7-6-8-15(16)19/h6-8,12,19H,4-5,9-11H2,1-3H3
InChIKey
HVOYRIYIBILDHN-UHFFFAOYSA-N
PubChem Compound ID
44404886
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527668]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

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