Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0AU0F
|
||||
Former ID |
DIB021142
|
||||
Drug Name |
UR-PG146
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Discovery agent | Investigative | [1] | ||
Structure |
![]() |
Download2D MOL |
|||
Formula |
C14H21N7OS
|
||||
InChI |
InChI=1S/C14H21N7OS/c1-10-12(20-9-18-10)6-23-7-13(22)21-14(15)17-4-2-3-11-5-16-8-19-11/h5,8-9H,2-4,6-7H2,1H3,(H,16,19)(H,18,20)(H3,15,17,21,22)
|
||||
InChIKey |
ZOBGKPFWPWGQOI-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H1 receptor | Target Info | Agonist | [2] | |
Histamine H2 receptor | Target Info | Agonist | [2] | ||
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Histamine H1 receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors | |||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
IL-4 Signaling Pathway | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1200). | ||||
REF 2 | Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.