TTD | Drug: D0B1KT

Drug General Information
Drug ID	D0B1KT
Former ID	DIB018761
Drug Name	AF353
Synonyms	AF-353; AF 353
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[467469]
Structure		Download 2D MOL
Formula	C14H17IN4O2
InChI	InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
InChIKey	AATPYXMXFBBKFO-UHFFFAOYSA-N
PubChem Compound ID	15953802
PubChem Substance ID	22425373, 26559730, 33336708, 103612778, 104108644, 125646956, 131328439, 137548780, 162660567, 172918128, 178100947, 223968401, 227699018, 246650854
Target and Pathway
Target(s)	P2X purinoceptor 3	Target Info	Antagonist	[531000]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
References
Ref 467469	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4125).
Ref 531000	AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-98.

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Drug Information