Drug Information

Drug General Information
Drug ID
D0B1TS
Former ID
DNC001064
Drug Name
Orotate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535811]
Structure
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2D MOL

3D MOL
Formula
C5H3N2O4-
Canonical SMILES
C1=C(NC(=O)NC1=O)C(=O)[O-]
InChI
1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1
InChIKey
PXQPEWDEAKTCGB-UHFFFAOYSA-M
CAS Number
CAS 88495-63-0
PubChem Compound ID
1492348
PubChem Substance ID
3032, 4764781, 6316686, 8145382, 50259498, 60710903, 110455099, 125676400, 127307863, 127307864, 127307865, 137248608, 137733736, 162907330, 184584684, 223501174
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [535811]
Dihydroorotase Target Info Inhibitor [535811]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.

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