Drug General Information
Drug ID	D0B2CQ
Former ID	DIB001201
Drug Name	GR-131663
Synonyms	AH-002; AH-017; GR-131665
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[545488]
Company	Glaxo Group Research Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(CCC(NC(=O)CCl)C1)cccc2OC
CAS Number	CAS 134865-72-8
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Modulator	[525346]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545488	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003455)
Ref 525346	Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur J Pharmacol. 1999 Oct 15;382(3):157-66.

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