Drug Information

Drug General Information
Drug ID
D0B2MD
Former ID
DIB018236
Drug Name
[3H]alniditan
Synonyms
R-91274
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538688]
Structure
Download
2D MOL
Formula
C17H26N4O
InChI
InChI=1S/C17H26N4O/c1-2-6-16-14(5-1)7-8-15(22-16)13-18-9-3-10-19-17-20-11-4-12-21-17/h1-2,5-6,15,18H,3-4,7-13H2,(H2,19,20,21)/t15-/m1/s1
InChIKey
QVSXOXCYXPQXMF-OAHLLOKOSA-N
PubChem Compound ID
66004
PubChem Substance ID
8190097, 14898506, 14923025, 43122726, 47954505, 48329100, 50177034, 103297667, 104335231, 117518538, 129082041, 135024195, 135649920, 135651134, 137263410, 163352527, 179149980, 198978671, 227007062
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [534635]
5-hydroxytryptamine 1B receptor Target Info Agonist [534635]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538688(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 117).
Ref 534635Br J Pharmacol. 1998 Apr;123(8):1655-65.Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.

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