Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B6JV
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| Former ID |
DNC004058
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| Drug Name |
SB-201993
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| Drug Type |
Small molecular drug
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| Indication | Psoriasis [ICD9: 696; ICD10:L40] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C32H37NO6S
|
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| Canonical SMILES |
COC1=CC=C(C=C1)CCCCCCCCOC2=C(N=C(C=C2)CSCC3=CC=CC(=C3)C<br />(=O)O)C=CC(=O)O
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| InChI |
1S/C32H37NO6S/c1-38-28-15-12-24(13-16-28)9-6-4-2-3-5-7-20-39-30-18-14-27(33-29(30)17-19-31(34)35)23-40-22-25-10-8-11-26(21-25)32(36)37/h8,10-19,21H,2-7,9,20,22-23H2,1H3,(H,34,35)(H,36,37)/b19-17+
|
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| InChIKey |
QQUXZUFSDIOIFJ-HTXNQAPBSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Leukotriene B4 receptor 1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| Reactome | Leukotriene receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003335) | ||||
| REF 2 | J Med Chem. 1996 Sep 13;39(19):3837-41.(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity. | ||||
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