TTD | Drug: D0B6JV

Drug General Information
Drug ID	D0B6JV
Former ID	DNC004058
Drug Name	SB-201993
Drug Type	Small molecular drug
Indication	Psoriasis [ICD9: 696; ICD10:L40]		Discontinued in Phase 2	[545457]
Structure		Download 2D MOL 3D MOL
Formula	C32H37NO6S
Canonical SMILES	COC1=CC=C(C=C1)CCCCCCCCOC2=C(N=C(C=C2)CSCC3=CC=CC(=C3)C<br />(=O)O)C=CC(=O)O
InChI	1S/C32H37NO6S/c1-38-28-15-12-24(13-16-28)9-6-4-2-3-5-7-20-39-30-18-14-27(33-29(30)17-19-31(34)35)23-40-22-25-10-8-11-26(21-25)32(36)37/h8,10-19,21H,2-7,9,20,22-23H2,1H3,(H,34,35)(H,36,37)/b19-17+
InChIKey	QQUXZUFSDIOIFJ-HTXNQAPBSA-N
PubChem Compound ID	6435820
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Inhibitor	[534210]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545457	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003335)
Ref 534210	J Med Chem. 1996 Sep 13;39(19):3837-41.(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.

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Drug Information