Drug Information

Drug General Information
Drug ID
D0B7YT
Former ID
DAP000343
Drug Name
Scopolamine
Synonyms
Atrochin; Atroquin; Atroscine; Beldavrin; Euscopol; Hyosceine; Hyoscine; Hyosol; Hysco; Isoscopil; Kwells; Oscine; SEE; Scop; Scopamin; Scopolaminhydrobromid; Scopos; Sereen; Skopolamin; Tranaxine; Transcop; Triptone; Atroscine Hydrobromide; Epoxytropine tropate; Hydroscine hydrobromide; Hyocine F hydrobromide; Hyoscine bromide; Hyoscyine hydrobromide; Isopto Hyoscine; SCOPOLAMINE BROMIDE; Scopine tropate; Scopolamine Hyoscine; Scopolaminium bromide; Scopolammonium bromide; Transderm scop; Tropane alkaloid; MOLI001381; NCI61806; Borrachero (TN); Burundanga (TN); Hyoscine (TN); L-Hyoscine hydrobromide; L-Scopolamine; Scopoderm-TTS; Scopolamine (INN); Transderm scop (TN); Transderm-Scop; Transderm-V; Tropic acid, ester with scopine; Levo-duboisine (TN); Scopine (-)-tropate; Xy-, (-)-tropate (ester); Tropic acid, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4))non-7-yl ester; (+)-Hyoscine; (+)-Scopolamine; (-)-Hyoscine; (-)-Scopolamine; (-)-Scopolamine hydrobromide trihydrate; (1S,3S,5R,6R,7S)-6,7-epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate; 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epo; 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-, (-)-tropate (ester); 3-Oxa-9-azatricyclo(3.3.1.0(sup 2,4))nonan-7-ol, 9-methyl-, tropate (ester); 3-Oxa-9-azatricyclo(3.3.1.O(sup 2,4))nonan-7-ol, 9-methyl-, tropate (ester); 6,7-Epoxytropine tropate; 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate; 6beta,7beta-Epoxy-1alpha,5alpha-tropan-3alpha-ol; 6beta,7beta-Epoxy-3alpha-tropanyl S-(-)-tropate; 9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl tropate
Drug Type
Small molecular drug
Indication Nausea; Addiction [ICD9: 303-305, 787.0; ICD10:F10-F19, R11] Approved [540261], [551436]
Therapeutic Class
Antispasmodics
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO4
InChI
InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1
InChIKey
STECJAGHUSJQJN-FWXGHANASA-N
CAS Number
CAS 51-34-3
PubChem Compound ID
10267087
PubChem Substance ID
15271797, 41252319, 76199435
ChEBI ID
ChEBI:16794
SuperDrug ATC ID
A04AD01; N05CM05; S01FA02
SuperDrug CAS ID
cas=000051343
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Antagonist [536730], [537137]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540261(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 330).
Ref 551436Drug Information of Calcidiol from nextbio research in illumina. 2015.
Ref 536730Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release. Neuroreport. 2008 Jun 11;19(9):991-5.
Ref 537137The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors. Neuroscience. 2009 May 5;160(2):255-63. Epub 2009 Mar 9.

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