Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B9OG
|
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| Former ID |
DIB005977
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| Drug Name |
Adipiplon
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| Synonyms |
GABA modulator (insomnia), Neurogen; NG-2-73
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| Drug Type |
Small molecular drug
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| Indication | Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] | Phase 2 | [1] | ||
| Company |
Neurogen Corporation
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H18FN7
|
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| Canonical SMILES |
c1n2c(c(c(n1)Cn1c(ncc1)c1c(cccn1)F)CCC)nc(n2)C
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| CAS Number |
CAS 840486-93-3
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00683436) Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs. U.S. National Institutes of Health. | ||||
| REF 2 | Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3. | ||||
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